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Methylswertianin

Names

[ CAS No. ]:
22172-17-4

[ Name ]:
Methylswertianin

[Synonym ]:
1,8-dihydroxy-2,6-dimethoxyxanthen-9-one
7-O-methyl swertianin
Swertiaperennin
Xanthen-9-one,1,8-dihydroxy-2,6-dimethoxy
metylswertianin
Methylswertianin
9H-Xanthen-9-one, 1,8-dihydroxy-2,6-dimethoxy-
1,8-Dihydroxy-2,6-dimethoxy-9H-xanthen-9-one
1,8-dihydroxy-3,7-dimethoxyxanthone
swertsiaperennin
1,8-Dihydroxy-2,6-dimethoxyxanthone
2-O-Methylswertianin

Biological Activity

[Description]:

Methylswertianin is an active constituent in Swertia punicea Hemsl, with anti-diabetic effect. Methylswertianin could be useful for treating type-2 diabetes, likely via the improvement of insulin resistance (IR)[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[References]

[1]. Tian LY, et al. Anti-diabetic effect of methylswertianin and bellidifolin from Swertia punicea Hemsl. and its potential mechanism. Phytomedicine. 2010 Jun;17(7):533-9.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
546.3±50.0 °C at 760 mmHg

[ Melting Point ]:
191-192℃

[ Molecular Formula ]:
C15H12O6

[ Molecular Weight ]:
288.252

[ Flash Point ]:
210.7±23.6 °C

[ Exact Mass ]:
288.063385

[ PSA ]:
89.13000

[ LogP ]:
1.66

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.653

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ZD6034200
CHEMICAL NAME :
Xanthen-9-one, 1,8-dihydroxy-2,6-dimethoxy-
CAS REGISTRY NUMBER :
22172-17-4
BEILSTEIN REFERENCE NO. :
1351740
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C15-H12-O6
MOLECULAR WEIGHT :
288.27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
100 ug/plate
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 32,2290,1984

Safety Information

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%