PF-06815189

PF-06815189 is a potent, selective phosphodiesterase 2 (PDE2) inhibitor with IC50 of 0.4 nM, >1,000-fold selectivity over PDE5; also demonstrates no significant activities (EC50 >10 μM) in a broad spectrum BioPrint panel; possesses favorable pharmacological and in vitro ADME profile, the pharmacokinetic attributes.

References 1. Stepan AF, et al. ACS Med Chem Lett. 2018 Jan 4;9(2):68-72. View Related Products by Target Phosphodiesterase (PDE)