Benzamide,5-chloro-N-(3-chlorophenyl)-2-hydroxy-

Names

[ Name ]:
Benzamide,5-chloro-N-(3-chlorophenyl)-2-hydroxy-

[Synonym ]:
3',5-dichlorosalicylanilide

Biological Activity

[Description]:

SARS-CoV-2-IN-14 (compound 6) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.39 μM. SARS-CoV-2-IN-14 is a niclosamide analogue. SARS-CoV-2-IN-14 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> SARS-CoV

[References]

[1]. Juang YP, et al. Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2. Eur J Med Chem. 2022 May 5;235:114295.

Chemical & Physical Properties

[ Density]:
1.479g/cm3

[ Boiling Point ]:
361.5ºC at 760 mmHg

[ Molecular Formula ]:
C₁₃H₉Cl₂NO₂

[ Molecular Weight ]:
282.12

[ Flash Point ]:
172.4ºC

[ Exact Mass ]:
281.00100

[ PSA ]:
49.33000

[ LogP ]:
4.02430

[ Vapour Pressure ]:
9.91E-06mmHg at 25°C

[ Index of Refraction ]:
1.685

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xn

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%