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SHP504

Names

[ CAS No. ]:
2222280-83-1

[ Name ]:
SHP504

[Synonym ]:
3-(4-(2-chlorobenzyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)-4-hydroxybenzoic acid

Biological Activity

[Description]:

SHP504 is a SHP2 phosphatase inhibitor, with an IC50 of 21 μM for SHP21–525[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

[References]

[1]. Michelle Fodor, et al. Dual Allosteric Inhibition of SHP2 Phosphatase. ACS Chem Biol. 2018 Mar 16;13(3):647-656.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H15ClN4O4

[ Molecular Weight ]:
446.84

[ Storage condition ]:
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO