SNIPER(ABL)-039

Names

[ Name ]:
SNIPER(ABL)-039

Biological Activity

[Description]:

SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl

[Target]

Abl:0.54 nM (IC50)

cIAP1:10 nM (IC50)

cIAP2:12 nM (IC50)

XIAP:50 nM (IC50)

SNIPER

Abl:10 nM (DC50)

[References]

[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₄H₆₈ClN₁₁O₉S₂

[ Molecular Weight ]:
1114.77

SNIPER(ABL)-039

Names

Biological Activity

Chemical & Physical Properties

Related Compounds