FM-479

Names

[ Name ]:
FM-479

Biological Activity

[Description]:

FM-479 is the negative control of FM-381 (HY-102046) and has no activity on JAK3 or other kinases[1]. FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.

[Related Catalog]:

Signaling Pathways >> JAK/STAT Signaling >> JAK

Signaling Pathways >> Epigenetics >> JAK

Signaling Pathways >> Stem Cell/Wnt >> JAK

Research Areas >> Inflammation/Immunology

[Target]

JAK3

[In Vitro]

FM-479 is the inactive control of FM-381, the concentration used in assays is similar[1].

[References]

[1]. https://www.thesgc.org/chemical-probes/FM-381

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₆N₆O₂

[ Molecular Weight ]:
442.51

FM-479

Names

Biological Activity

Chemical & Physical Properties

Related Compounds