<Suppliers Price>

Aurora inhibitor 1

Names

[ CAS No. ]:
2227019-45-4

[ Name ]:
Aurora inhibitor 1

Biological Activity

[Description]:

Aurora inhibitor 1 is a potent Aurora inhibitor with an IC50 of ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase, respectively[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Aurora Kinase
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase

[Target]

Aurora A:4 nM (IC50)

Aurora B:13 nM (IC50)


[In Vitro]

Aurora inhibitor 1 (Compound 16) exhibits Kd values of 0.01 nM for both Aurora A and Aurora B kinase[1].

[In Vivo]

Aurora inhibitor 1 (Compound 16) exhibits good drug exposure levels across species upon oral dosing, and shows excellent in vivo efficacy in a mouse xenograft tumor model when dosed orally[1].

[References]

[1]. Yu T, et al. Discovery of a highly potent orally bioavailable imidazo-[1, 2-a]pyrazine Aurora inhibitor. Bioorg Med Chem Lett. 2018 May 1;28(8):1397-1403.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H25N9S

[ Molecular Weight ]:
459.57

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds