SOS1 activator 17

SOS1 activator 17 is a small molecule activator of guanine nucleotide exchange factor SOS1 with EC50 of 0.8 uM, modulates RAS signaling in vitro; activates the nucleotide exchange process at submicromolar concentrations in vitro, increases levels of active RAS-GTP in HeLa cells, and elicits signaling changes in the MAPK-ERK pathway, resulting in a decrease in pERK1/2T202/Y204 protein levels.

References 1. Abbott JR, et al. J Med Chem. 2018 Jul 11. doi: 10.1021/acs.jmedchem.8b00360. View Related Products by Target Ras