(S,R,S)-AHPC-Me-C5-COOH

Names

[ Name ]:
(S,R,S)-AHPC-Me-C5-COOH

Biological Activity

[Description]:

(S,R,S)-AHPC-Me-C5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C5-COOH can be used in PROTAC DT2216 (HY-130604)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

VHL

[In Vitro]

DT2216 is a selective B-cell lymphoma extra large (BCL-XL) PROTAC degrader[1].

[References]

[1]. Khan S, et al. A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Nat Med. 2019 Dec;25(12):1938-1947.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₄₂N₄O₆S

[ Molecular Weight ]:
586.74

Safety Information

[ Hazard Codes ]:
Xi

(S,R,S)-AHPC-Me-C5-COOH

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds