Thalidomide-5-PEG2-Cl

Names

[ Name ]:
Thalidomide-5-PEG2-Cl

Biological Activity

[Description]:

Thalidomide-5-PEG2-Cl is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-PEG2-Cl can be connected to the ligand for protein by a linker to form PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

Cereblon

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-994.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₇ClN₂O₆

[ Molecular Weight ]:
380.78

[ Storage condition ]:
2-8°C

Thalidomide-5-PEG2-Cl

Names

Biological Activity

Chemical & Physical Properties

Related Compounds