BMT-090605 hydrochloride
Names
[ CAS No. ]:
2231664-45-0
[ Name ]:
BMT-090605 hydrochloride
Biological Activity
[Description]:
BMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic pain[1].
[Related Catalog]:
[Target]
IC50: 0.6 nM (AAK1); 45 nM (BIKE); 60 nM (GAK)[1]
[In Vitro]
BMT-090605 hydrochloride shows AAK1inhibitory activity with an IC50 of 0.63 nM[1]. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively[1].
[In Vivo]
BMT-090605 hydrochloride(intrathecal; 0.3-3 µg/rat) causes antinociception by inhibiting AAK1 in the spinal cord[1]. Animal Model: Male Sprague-Dawley rats (chronic constriction injury (CCI) model)[1] Dosage: 0.3-3 µg/rat Administration: Intrathecal Result: Caused a dose-dependent reduction in thermal hyperalgesia.
Chemical & Physical Properties
[ Molecular Formula ]:
C21H25ClN4O2
[ Molecular Weight ]:
400.90