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DMA-135 hydrochloride

Names

[ CAS No. ]:
2237925-62-9

[ Name ]:
DMA-135 hydrochloride

Biological Activity

[Description]:

DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication. DMA-135 hydrochloride binds to enterovirus 71 (EV71) SLII domain with moderately high affinity (KD= 520 nM). DMA-135 hydrochloride has no significant toxicity in cell-based studies[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Davila-Calderon J, Patwardhan NN, Chiu LY, et al. IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex. Nat Commun. 2020;11(1):4775. Published 2020 Sep 22.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H18ClN7O

[ Molecular Weight ]:
359.81

Related Compounds