GAK inhibitor 12r

GAK inhibitor 12r is a higghly potent, selective inhibitor of cyclin G-associated kinase (GAK) with Kd of 89 nM; targets only 8 other kinases with greater than 90% inhibition in a diverse panel of 468 kinases; demonstrates broad-spectrum antiviral activity with EC50 of 0.82 uM against DENV-2, also shows activity against dengue virus, including in human primary dendritic cells, and efficacy against the unrelated Ebola and chikungunya viruses.

References 1. Pu SY, et al. J Med Chem. 2018 Jul 16. doi: 10.1021/acs.jmedchem.8b00613. View Related Products by Target Other Targets