SMS2-IN-2

Names

[ Name ]:
SMS2-IN-2

Biological Activity

[Description]:

SMS2-IN-2 is a potent, highly selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with IC50s of 100 nM and 56 μM for SMS2 and SMS1, respectively. Anti-chronic inflammatory activity[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Target]

IC50: 100 nM (SMS2), 56 μM (SMS1)[1]

[In Vivo]

SMS2-IN-2 (Compound 15w; 20, 50 mg/kg/day, p.o. for 6 weeks) reduces chronic inflammation in the db/db mice[1]. Animal Model: Type 2 diabetes mellitus (T2DM) db/db mouse model (four-to-five week)[1] Dosage: 20, 50 mg/kg/day Administration: P.O. daily for 6 weeks Result: Significantly reduced IL-6 and insulin levels.

[References]

[1]. Mo M, et al. Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice. J Med Chem. 2018 Sep 27;61(18):8241-8254.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₃ClFN₃O₂

[ Molecular Weight ]:
369.78

SMS2-IN-2

Names

Biological Activity

Chemical & Physical Properties

Related Compounds