GPR84 antagonist 2

Names

[ Name ]:
GPR84 antagonist 2

Biological Activity

[Description]:

GPR84 antagonist 2 (compound 33) is a potent, selective, and orally active GPR84 antagonist (IC50=8.95 nM). GPR84 antagonist 2 shows improved potency in the calcium mobilization assay and the ability to inhibit the chemotaxis of neutrophils and macrophages upon GPR84 activation. GPR84 antagonist 2 has the potential for the research of ulcerative colitis[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> GPR84

[References]

[1]. Chen LH, et al. Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis. J Med Chem. 2022;65(5):3991-4006.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₁₆Cl₂NaO₄PS₂

[ Molecular Weight ]:
605.42

GPR84 antagonist 2

Names

Biological Activity

Chemical & Physical Properties

Related Compounds