VH 032, phenol

Names

[ Name ]:
VH 032, phenol

Biological Activity

[Description]:

VH032-OH is the VH032-based VHL ligand. VH032-OH can be connected to the ligand for protein by a linker to form PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

VHL

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017;8(1):830. Published 2017 Oct 10.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₃₂N₄O₅S

[ Molecular Weight ]:
488.60

Safety Information

[ Hazard Codes ]:
Xi

VH 032, phenol

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds