ELA-21 (human)

Names

[ Name ]:
ELA-21 (human)

Biological Activity

[Description]:

ELA-21 (human) is an apelin receptor agonist with a pKi of 8.52. ELA-21 (human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment with subnanomolar potencies. ELA-21 (human) is an agonist in G-protein-dependent and -independent pathways[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Peiran Yang, et al. Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension. Circulation. 2017 Mar 21;135(12):1160-1173.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁₂H₁₈₄N₄₀O₂₅S₃

[ Molecular Weight ]:
2587.14

ELA-21 (human)

Names

Biological Activity

Chemical & Physical Properties

Related Compounds