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SGLT inhibitor-1

Names

[ CAS No. ]:
2247314-23-2

[ Name ]:
SGLT inhibitor-1

Biological Activity

[Description]:

SGLT inhibitor-1 is a potent dual inhibitor of sodium glucose co-transporter proteins (SGLTs), inhibits hSGLT1 and hSGLT2 with IC50s of 43 nM and 9 nM, respectively[1].

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> SGLT

[Target]

IC50: 43 nM (hSGLT1), 9 nM (hSGLT2)[1]


[References]

[1]. Xu G， et al. Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors. Bioorg Med Chem Lett. 2018 Nov 15;28(21):3446-3453.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H27FO8

[ Molecular Weight ]:
462.46

Related Compounds