Py-MAA-Val-Cit-PAB-MMAE

Names

[ Name ]:
Py-MAA-Val-Cit-PAB-MMAE

Biological Activity

[Description]:

Py-MAA-Val-Cit-PAB-MMAE (AAJ8D6-PY-Val-Cit-MMAE) is an ADC Linker of Zapadcine-3a. Zapadcine-3a is an anti-TRAILR2 ADC with broad spectrum, and antineoplastic effect. Zapadcine-3a can be swallowed up into lysosome of tumor cells by binding to TRAILR2. Then Zapadcine-3a releases small molecular compound to specifically kill various TRAILR2-pos. Zapadcine-3a potently eradicates tumor cells and cures tumor[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

CD262

[References]

[1]. Zheng Dexia, et al. Anti-tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAILR2) antibody-drug conjugate (ADC) and its pharmaceutical application in antineoplastic therapy: China, CN108452320. 2018-08-28.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇₂H₁₁₁N₁₃O₁₆S

[ Molecular Weight ]:
1446.79

Py-MAA-Val-Cit-PAB-MMAE

Names

Biological Activity

Chemical & Physical Properties

Related Compounds