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Falcarindiol

Names

[ CAS No. ]:
225110-25-8

[ Name ]:
Falcarindiol

[Synonym ]:
(9Z)-1,9-Heptadecadiene-4,6-diyne-3,8-diol
1,9-Heptadecadiene-4,6-diyne-3,8-diol, (9Z)-
Falcarindiol
(9Z)-Heptadeca-1,9-diene-4,6-diyne-3,8-diol
1,9-HEPTADECADIENE-4,6-DIYNE-3,8-DIOL,(3R,8S,9Z)-
(3R,8S)-Falcarindiol

Biological Activity

[Description]:

(+)-(3R,8S)-Falcarindiol is a polyacetylene found in carrots, has antimycobacterial activity, with an IC50 of 6 μM and MIC of 24 μM against Mycobacterium tuberculosis H37Ra[1][2]. Antineoplastic and anti-inflammatory activity[2].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 6 μM (Mycobacterium tuberculosis H37Ra)[1]


[References]

[1]. O'Neill T, et al. The Canadian medicinal plant Heracleum maximum contains antimycobacterial diynes and furanocoumarins. J Ethnopharmacol. 2013 May 2;147(1):232-7.

[2]. Kobaek-Larsen M, et al. Effect of the dietary polyacetylenes falcarinol and falcarindiol on the gut microbiota composition in a rat model of colorectal cancer. BMC Res Notes. 2018 Jun 27;11(1):411.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
408.2±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H24O2

[ Molecular Weight ]:
260.37

[ Flash Point ]:
184.7±23.3 °C

[ Exact Mass ]:
260.177643

[ PSA ]:
40.46000

[ LogP ]:
6.32

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.524

Safety Information

[ Hazard Codes ]:
Xi

Precursor & DownStream

Precursor

DownStream

Related Compounds