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DDO-7263

Names

[ CAS No. ]:
2254004-96-9

[ Name ]:
DDO-7263

Biological Activity

[Description]:

DDO-7263, a 1,2,4-Oxadiazole derivative, is a potent Nrf2 activator. DDO-7263 upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 activates the Nrf2-ARE signaling pathway and exerts anti-inflammatory activity[1].

[Related Catalog]:

Signaling Pathways >> NF-κB >> Keap1-Nrf2
Research Areas >> Inflammation/Immunology

[References]

[1]. Zhen Dai, et al. Target Fishing Reveals a Novel Mechanism of 1,2,4-Oxadiazole Derivatives Targeting Rpn6, a Subunit of 26S Proteasome. J Med Chem. 2022 Mar 24;65(6):5029-5043.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H9F2N3O

[ Molecular Weight ]:
273.24

Related Compounds