<Suppliers Price>

SGC-iMLLT

Names

[ CAS No. ]:
2255338-25-9

[ Name ]:
SGC-iMLLT

Biological Activity

[Description]:

SGC-iMLLT is a potent and selective inhibitor of MLLT1/3-histone interactions, occupies the Kac/Kcr binding site of MLLT1 YD (ENL/YEATS1), with high binding activity at MLLT1 YD (IC50, 0.26 μM; Kd, 0.129 μM) and MLLT3 YD (AF9/YEATS3) (Kd, 0.077 μM)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

IC50: 0.26 μM (MLLT1 YD)[1] Kd: 0.077 μM (MLLT3 YD), 0.129 μM (MLLT1 YD)[1]


[References]

[1]. Moustakim M, et al. Discovery of an MLLT1/3 YEATS Domain Chemical Probe. Angew Chem Int Ed Engl. 2018 Dec 10;57(50):16302-16307.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H24N6O

[ Molecular Weight ]:
388.47

[ Storage condition ]:
2-8℃

Related Compounds