BCL6 PROTAC 1

Names

[ CAS No. ]:
2257479-54-0

[ Name ]:
BCL6 PROTAC 1

Biological Activity

[Description]:

BCL6 PROTAC 1 is a selective B-cell lymphoma 6 (BCL6) PROTAC. BCL6 PROTAC 1 inhibits BCL6 cell reporter with an IC50 value of 8.8 µM. BCL6 PROTAC 1 significantly degrades BCL6 in diffuse large B-cell lymphoma (DLBCL) cell lines. BCL6 PROTAC 1 can be used in tumor related research[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family
Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC

[Target]

B-cell lymphoma 6, BCL6[1]


[In Vitro]

BCL6 PROTAC 1 (Compound 15) (0.0001-10 µM；1-72 h) 在 OCI-Ly1 细胞中，以剂量依赖性方式降解 B 细胞淋巴瘤 6 (BCL6)[1]。 Cell Viability Assay[1] Cell Line: OCI-Ly1 cells. Concentration: 1 µM. Incubation Time: 16 d. Result: Had no effect on cell viability. Western Blot Analysis[1] Cell Line: OCI-Ly1 cells. Concentration: 0.0001, 0.001, 0.01, 0.1, 0.2, 1, 3, 5 and 10 µM. Incubation Time: 1, 2, 4, 6, 8, 10, 24, 48, 72 h. Result: Degraded BCL6.

[References]

[1]. McCoull W, et al. Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6. ACS Chem Biol. 2018 Nov 16;13(11):3131-3141.  

Chemical & Physical Properties

[ Molecular Formula ]:
C45H52ClN9O12

[ Molecular Weight ]:
946.40

Related Compounds