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NPS 2390

Names

[ CAS No. ]:
226878-01-9

[ Name ]:
NPS 2390

[Synonym ]:
N-(tricyclo[3.3.1.1]dec-1-yl)quinoxaline-2-carboxamide
2-quinoxaline-carboxamide-N-adamantan-1-yl
N-(Adamantan-1-yl)-2-quinoxalinecarboxamide
2-Quinoxalinecarboxamide, N-tricyclo[3.3.1.1]dec-1-yl-
Quinoxaline-2-carboxylic acid adamantan-1-ylamide
NPS 2390

Biological Activity

[Description]:

NPS 2390 is a noncompetitive antagonist of mGluR1 and mGluR5[1]. NPS 2390 is also a potent CaSR (calcium-sensing receptor) inhibitor[2][3].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> mGluR
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> CaSR

[Target]

mGluR1

mGluR5


[References]

[1]. Vanejevs M, et al. Positive and negative modulation of group I metabotropic glutamate receptors. J Med Chem. 2008 Feb 14;51(3):634-47.

[2]. Peng X, et al. NPS2390, a Selective Calcium-sensing Receptor Antagonist Controls the Phenotypic Modulation of Hypoxic Human Pulmonary Arterial Smooth Muscle Cells by Regulating Autophagy. J Transl Int Med. 2019 Jul 11;7(2):59-68.

[3]. Xue Z, et al. Calcium-sensing receptor antagonist NPS2390 attenuates neuronal apoptosis though intrinsic pathway following traumatic brain injury in rats. Biochem Biophys Res Commun. 2017 Apr 29;486(2):589-594.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
542.4±30.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H21N3O

[ Molecular Weight ]:
307.389

[ Flash Point ]:
281.9±24.6 °C

[ Exact Mass ]:
307.168457

[ PSA ]:
54.88000

[ LogP ]:
3.65

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.658

MSDS

Click to get detail MSDS

Precursor & DownStream

Precursor

DownStream

Related Compounds