IONIS-FB-LRx

Names

[ CAS No. ]:
2272975-74-1

[ Name ]:
IONIS-FB-LRx

Biological Activity

[Description]:

IONIS-FB-LRx is a specific antisense oligonucleotide (ASO) targeting complement factor B (CFB). IONIS-FB-LRx effectively reduces circulating levels of CFB. IONIS-FB-LRx can be used for geographic atrophy (GA) research[1][2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Immunology/Inflammation >> Complement System

[Target]

Complement factor B (CFB)[1]


[In Vivo]

IONIS-FB-Lrx is administered by subcutaneous injection every four weeks and targets CFB’s hepatic expression[2].

[References]

[1]. Dreismann AK, et al. Gene targeting as a therapeutic avenue in diseases mediated by the complement alternative pathway. Immunol Rev. 2022 Nov 12.  

[2]. Mahmoudzadeh R, et al. Emerging treatments for geographic atrophy in age-related macular degeneration. Curr Opin Ophthalmol. 2021 May 1;32(3):294-300.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds