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HIP-B

Names

[ CAS No. ]:
227619-65-0

[ Name ]:
HIP-B

[Synonym ]:
hip-b

Biological Activity

[Description]:

(±)-HIP-B is a non-competitive excitatory amino acid transporter (EAAT) blocker that effectively blocks Glu uptake (IC50=17-18 μM). (±)-HIP-B is also a lead compound against ischemia-induced neuronal degeneration. (±)-HIP-B can be used in the study of neurological diseases[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> EAAT2
Research Areas >> Neurological Disease

[References]

[1]. Andrea Pinto, et al. Synthesis of enantiomerically pure HIP-A and HIP-B and investigation of their activity as inhibitors of excitatory amino acid transporters.

Chemical & Physical Properties

[ Molecular Formula ]:
C6H8N2O4

[ Molecular Weight ]:
172.14

[ Exact Mass ]:
172.04800

[ PSA ]:
91.15000

Related Compounds