Xanthine oxidase-IN-5

Names

[ CAS No. ]:
2276711-87-4

[ Name ]:
Xanthine oxidase-IN-5

Biological Activity

[Description]:

Xanthine oxidase-IN-5 is an effective and orally active xanthine oxidase (XO) inhibitor with IC50 value of 0.70 μM. Xanthine oxidase-IN-5 displays favorable drug-like properties with ligand efficiency (LE) and lipophilic ligand efficiency (LLE) values of 0.33 and 3.41, respectively. Xanthine oxidase-IN-5 shows potent hypouricemic effects in hyperuricemic rat model[1].

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase

[Target]

IC50: 0.70 μM (XO)[1]


[In Vivo]

Xanthine oxidase-IN-5 (compound 9m) shows potent hypouricemic effects at an oral dose of 20 mg/kg in a rat hyperuricemia model induced by potassium oxonate[1]. Animal Model: Potassium oxonate-induced hyperuricemic rat model[1] Dosage: 20 mg/kg Administration: PO; single (measured serum uric acid after 0.5 - 8 hours) Result: Showed potent hypouricemic effects at an oral dose of 20 mg/kg in a rat hyperuricemia model induced by potassium oxonate.

[References]

[1]. Zhang TJ, Zhang Y, Zhang ZH, et al. Discovery of 4-(phenoxymethyl)-1H-1,2,3-triazole derivatives as novel xanthine oxidase inhibitors. Bioorg Med Chem Lett. 2022;60:128582.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H16FN3O3

[ Molecular Weight ]:
341.34

Related Compounds