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Aclerastide

Names

[ CAS No. ]:
227803-63-6

[ Name ]:
Aclerastide

[Synonym ]:
[3-(L-2-aminohexanoic acid)]angiotensin II-(1-7)-peptide
aclerastide
L-Proline, L-α-aspartyl-N5-(diaminomethylene)-L-ornithyl-L-norleucyl-L-tyrosyl-L-isoleucyl-L-histidyl-
L-α-Aspartyl-L-arginyl-L-norleucyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline
UNII:YYD6UT8T47

Biological Activity

[Description]:

Aclerastide (DSC-127) is an angiotensin receptor agonist. Aclerastide also is a peptide analog of angiotensin II. Aclerastide can be used for the research of tissue regeneration in diabetic ulcers[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor

[In Vivo]

Aclerastide (0.1 mg/wound; day for 5 days) shows superior efficacy in the db/db mouse model of wound healing[1]. Aclerastide (topically administered; 100 μL; once a day; for 14 days) elevates levels of reactive oxygen species and of active MMP-9[2]. Animal Model: db/db mice[2] Dosage: 100 μL Administration: Topically administered, once a day, for 14 days Result: Upregulated reactive oxygen species during inflammation. Increased the levels of the detrimental active MMP-9 in diabetic wounds.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C42H64N12O11

[ Molecular Weight ]:
913.031

[ Exact Mass ]:
912.481750

[ LogP ]:
1.46

[ Index of Refraction ]:
1.660

Related Compounds