Glucocerebrosidase-IN-1
Names
[ CAS No. ]:
2279945-76-3
[ Name ]:
Glucocerebrosidase-IN-1
Biological Activity
[Description]:
Glucocerebrosidase-IN-1 (compound 11a) is a potent and selective GCase (glucocerebrosidase) inhibitor, with an IC50 of 29.3 μM and a Ki of 18.5 μM. Glucocerebrosidase-IN-1 can be used for the research of Gaucher disease (GD) and Parkinson’s disease (PD)[1].
[Related Catalog]:
[Target]
IC50: 29.3 ± 1.8 μM (Glucocerebrosidase)[1]
[In Vitro]
Glucocerebrosidase-IN-1 (compound 11a) is able to enhance GCase activity 1.8-fold in fibroblasts bearing the homozygous L444P mutation[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C13H27NO3
[ Molecular Weight ]:
245.36