(D)-(-)-α-4-hydroxyphenyl glycine

Names

[ Name ]:
(D)-(-)-α-4-hydroxyphenyl glycine

[Synonym ]:
(D)-(-)-α-4-hydroxyphenyl glycine
(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid,4-Hydroxy-D-phenylglycine
D(-)-2-amino-(4-hydroxyphenyl)acetic acid
(R)-2-(4-Hydroxyphenyl)glycine
(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid,4-Hydroxy-D-phenylglycine,Cefadroxyl impurity A
D(-)-4-Hydroxyphenylglycine
Benzeneacetic acid, α-amino-4-hydroxy-, (αR)-
(2R)-2-Amino-2-(4
D-N-(4-Hydroxyphenyl)glycine
(2R)-Amino(4-hydroxyphenyl)acetic acid
D(-)-2-(4-hydroxyphenyl)glycine
(R)-(-)-2-Amino-2-(4-hydroxyphenyl)acetic acid
EINECS 245-247-7
MFCD00004262
(2R)-2-amino-2-(4-hydroxyphenyl)acetic acid
H-D-Phg(4-OH)-OH
(R)-2-Amino-2-(4-hydroxyphenyl)acetic acid
D-(-)-2-(4-Hydroxyphenyl)glycine
4-Hydroxy-D-phenylglycine
4-Hydroxy-D-(-)-2-phenylglycine
(D)-(-)-Alfa-4-hydroxyphenyl glycine
(R)-para-hydroxyphenylglycine
Amoxicillin Impurity 8

Biological Activity

[Description]:

D-4-Hydroxyphenylglycine (D-(-)-4-Hydroxyphenylglycine) is one of the most important raw materials used in the production of semisynthetic β-lactam antibiotics, such as Amoxicillin (HY-B0467A) and Cefadroxil (HY-B1190)[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Yu H, et al. Efficient biocatalytic production of D-4-hydroxyphenylglycine by whole cells of recombinant Ralstonia pickettii. Folia Microbiol (Praha). 2009;54(6):509-515.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
365.8±32.0 °C at 760 mmHg

[ Melting Point ]:
240 °C (dec.)(lit.)

[ Molecular Formula ]:
C₈H₉NO₃

[ Molecular Weight ]:
167.162

[ Flash Point ]:
175.0±25.1 °C

[ Exact Mass ]:
167.058243

[ PSA ]:
83.55000

[ LogP ]:
0.20

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.633

[ Water Solubility ]:
5 g/L (20 ºC)

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29225000

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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