Brosuximide
Names
[ CAS No. ]:
22855-57-8
[ Name ]:
Brosuximide
[Synonym ]:
3-(3-Bromophenyl)-2,5-pyrrolidinedione
Brosuximide
Brosuximida [INN-Spanish]
2-(m-Bromophenyl)succinimide
Imid kwasu 3-bromofenylobursztynowego [Polish]
3-Bromophenylsuccinimide
3-(3-bromophenyl)-pyrrolidine-2,5-dione
m-Bromophenylsuccinimide
Succinimide,2-(m-bromophenyl)
Brosuximidum [INN-Latin]
Chemical & Physical Properties
[ Density]:
1.606g/cm3
[ Boiling Point ]:
425.7ºC at 760mmHg
[ Molecular Formula ]:
C10H8BrNO2
[ Molecular Weight ]:
254.08000
[ Flash Point ]:
211.2ºC
[ Exact Mass ]:
252.97400
[ PSA ]:
49.66000
[ LogP ]:
1.85510
[ Vapour Pressure ]:
1.88E-07mmHg at 25°C
[ Index of Refraction ]:
1.601
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- WN2285000
- CHEMICAL NAME :
- Succinimide, 2-(m-bromophenyl)-
- CAS REGISTRY NUMBER :
- 22855-57-8
- BEILSTEIN REFERENCE NO. :
- 1457286
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C10-H8-Br-N-O2
- MOLECULAR WEIGHT :
- 254.10
- WISWESSER LINE NOTATION :
- T5VMVTJ DR CE
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1750 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - ataxia
- REFERENCE :
- APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937- Volume(issue)/page/year: 40,657,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 370 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland) V.18-24, 1966-72. For publisher information, see PJPPAA. Volume(issue)/page/year: 23,593,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 920 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937- Volume(issue)/page/year: 39,475,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 310 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 13,465,1978
Safety Information
[ HS Code ]:
2925190090
Customs
[ HS Code ]: 2925190090
[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%