Desmorpholinyl Quizartinib-PEG2-COOH

Names

[ Name ]:
Desmorpholinyl Quizartinib-PEG2-COOH

Biological Activity

[Description]:

Desmorpholinyl Quizartinib-PEG2-COOH incorporates a ligand for FLT-3, and a PEG-based PROTAC linker. Desmorpholinyl Quizartinib-PEG2-COOH can be used in the synthesis of PROTAC FLT-3 degrader 1 (HY-114323). PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM [1].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140(48):16428-16432.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₃₃N₅O₇S

[ Molecular Weight ]:
607.68

Safety Information

[ Hazard Codes ]:
Xi

Desmorpholinyl Quizartinib-PEG2-COOH

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds