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Apelin-36(rat, mouse)

Names

[ CAS No. ]:
230299-95-3

[ Name ]:
Apelin-36(rat, mouse)

Biological Activity

[Description]:

Apelin-36(rat, mouse) is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-36(rat, mouse) binds to APJ receptors with an IC50 of 5.4 nM, and potently inhibits cAMP production with an EC50 of 0.52 nM. Apelin-36(rat, mouse) blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection
Research Areas >> Metabolic Disease

[Target]

HIV-1

HIV-2


[References]

[1]. Kawamata Y, et al. Molecular properties of apelin: tissue distribution and receptor binding. Biochim Biophys Acta. 2001;1538(2-3):162-171.

[2]. Zou MX, et al. Apelin peptides block the entry of human immunodeficiency virus (HIV). FEBS Lett. 2000;473(1):15-18.

Chemical & Physical Properties

[ Molecular Formula ]:
C185H304N68O43S

[ Molecular Weight ]:
4200.93

Related Compounds