(+)-Muscarine (chloride)

Names

[ Name ]:
(+)-Muscarine (chloride)

[Synonym ]:
muscarine chloride
muscarine
((2S)-4c-hydroxy-5t-methyl-(2rH)-tetrahydro-furfuryl)-trimethyl-ammonium, chloride
((2S)-4c-Hydroxy-5t-methyl-(2rH)-tetrahydro-furfuryl)-trimethyl-ammonium, Chlorid

Biological Activity

[Description]:

Muscarine ((+)-Muscarine) chloride is a toxin that can stimulate the parasympathetic nervous system. Muscarine is a prototype muscarinic acetylcholine receptor agonist[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Neurological Disease

[In Vitro]

Muscarine administration (100 µM) induces an intracellular calcium signal amplitude similar to the one triggered by 10 µM ACh[1]. Muscarine (1-30 μM) produces a dose-dependent hyperpolarization in a sub-population of the NRM cells that contain 5-hydroxytryptamine (5-HT) on the NRM neurons[2].

[References]

[1]. Beatrice Mihaela Radu, et al. All muscarinic acetylcholine receptors (M 1-M 5) are expressed in murine brain microvascular endothelium. Sci Rep. 2017 Jul 11;7(1):5083.

[2]. Z Z Pan, et al. Muscarine hyperpolarizes a subpopulation of neurons by activating an M2 muscarinic receptor in rat nucleus raphe magnus in vitro. J Neurosci. 1994 Mar;14(3 Pt 1):1332-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₂₀ClNO₂

[ Molecular Weight ]:
209.71400

[ Exact Mass ]:
209.11800

[ PSA ]:
29.46000

[ LogP ]:
1.03290

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300-H310-H330

[ Precautionary Statements ]:
P260-P264-P280-P284-P302 + P350-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ RIDADR ]:
UN 2811 6.1 / PGII

[ RTECS ]:
QG3500000

Articles

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The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

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Neuregulin 1 (NRG1) is a trophic factor that has an essential role in the nervous system by modulating neurodevelopment, neurotransmission and synaptic plasticity. Despite the evidence that NRG1 and i...

FRET-based sensors for the human M1-, M3-, and M5-acetylcholine receptors.

Bioorg. Med. Chem. 19 , 1048-54, (2011)

Based on the recently developed approach to generate fluorescence resonance energy transfer (FRET)-based sensors to measure GPCR activation, we generated sensor constructs for the human M(1)-, M(3)-, ...