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VZ 185

Names

[ CAS No. ]:
2306193-61-1

[ Name ]:
VZ 185

Biological Activity

[Description]:

VZ185 is a potent, fast, and selective dual BRD7/9 PROTAC degrader with DC50s of 4.5 and 1.8 nM, respectively.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC

Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

DC50: 4.5 nM (BRD7), 1.8 nM (BRD9)[1]

[References]

[1]. Zoppi V, et al. Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7. J Med Chem. 2019 Jan 24;62(2):699-726.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₃H₆₇FN₈O₈S

[ Molecular Weight ]:
995.21

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds