Benzyl-PEG5-THP

Names

[ Name ]:
Benzyl-PEG5-THP

[Synonym ]:
MFCD29049394
2-[(1-Phenyl-2,5,8,11,14-pentaoxahexadecan-16-yl)oxy]tetrahydro-2H-pyran
2H-Pyran, tetrahydro-2-[(16-phenyl-3,6,9,12,15-pentaoxahexadec-1-yl)oxy]-

Biological Activity

[Description]:

Benzyl-PEG5-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
506.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₃₆O₇

[ Molecular Weight ]:
412.517

[ Flash Point ]:
197.3±30.0 °C

[ Exact Mass ]:
412.246094

[ LogP ]:
0.59

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.502

Benzyl-PEG5-THP

Names

Biological Activity

Chemical & Physical Properties

Related Compounds