Pip-alkyne-Ph-COOCH3

Names

[ CAS No. ]:
2308496-47-9

[ Name ]:
Pip-alkyne-Ph-COOCH3

Biological Activity

[Description]:

Pip-alkyne-Ph-COOCH3 is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTAC ARD-266[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain


[In Vitro]

ARD-266 is a a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader[1].

[References]

[1]. Han X, et al. Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands. J Med Chem. 2019 Dec 26;62(24):11218-11231.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H17NO2

[ Molecular Weight ]:
243.30

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds