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Neuropeptide SF(mouse,rat)

Names

[ CAS No. ]:
230960-31-3

[ Name ]:
Neuropeptide SF(mouse,rat)

Biological Activity

[Description]:

Neuropeptide SF (mouse,rat) is a potent neuropeptide FF receptor agonist with Ki values are 48.4 nM and 12.1 nM for NPFF1 and NPFF2, respectively. Neuropeptide SF increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) [1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor

[Target]

Ki: 48.4 nM (NPFF1) Ki: 12.1 nM (NPFF2)[1]


[References]

[1]. Miklós Jászberényi, et al. The actions of neuropeptide SF on the hypothalamic-pituitary-adrenal axis and behavior in rats.Regul Pept. 2014 Jan 10;188:46-51.

[2]. C Gouardères, et al. Quantitative autoradiographic distribution of NPFF1 neuropeptide FF receptor in the rat brain and comparison with NPFF2 receptor by using [125I]YVP and [(125I]EYF as selective radioligands. Neuroscience. 2002;115(2):349-61.

Chemical & Physical Properties

[ Molecular Formula ]:
C40H65N13O10

[ Molecular Weight ]:
888.02500

[ Exact Mass ]:
887.49800

[ PSA ]:
412.16000

[ LogP ]:
4.71880

Related Compounds