2-(4-(tert-Butyl)phenoxy)cyclohexyl prop-2-yn-1-yl sulfite

Names

[ Name ]:
2-(4-(tert-Butyl)phenoxy)cyclohexyl prop-2-yn-1-yl sulfite

[Synonym ]:
Propargite
d014
do14
Propargiet
Sulfurous acid, 2-[4-(1,1-dimethylethyl)phenoxy]cyclohexyl 2-propynyl ester
(1RS,2RS
comite
Sulfurous Acid 2-[4-(1,1-Dimethylethyl)phenoxy]cyclohexyl 2-Propynyl Ester
EINECS 219-006-1
2-[4-(2-Methyl-2-propanyl)phenoxy]cyclohexyl 2-propyn-1-yl sulfite
Omit
BPPS
MFCD00072448
Omite
progi
1RS,2SR)-2-(4-tert-butylphenoxy)cyclohexyl prop-2-ynyl sulfite
2-(4-tert-Butylphenoxy)cyclohexyl 2-propynyl sulfite
2-(4-tert-Butylphenoxy)cyclohexyl prop-2-yn-1-yl sulfite
PROP 57
omait
2-(4-tert-Butylphenoxy)cyclohexyl-prop-2-in-1-ylsulfit
Sulfurous Acid 2-(p-tert-Butylphenoxy)cyclohexyl 2-Propynyl Ester
(1Ξ,2Ξ)-2-(4-tert-butylphenoxy)cyclohexyl prop-2-yn-1-yl sulfite
Propargil
2-[4-(1,1-dimethylethyl)phenoxy]cyclohexyl 2-propyn-1-yl sulfite
Sulfurous acid, 2-[4-(1,1-dimethylethyl)phenoxy]cyclohexyl 2-propyn-1-yl ester
2-(4-(tert-Butyl)phenoxy)cyclohexyl prop-2-yn-1-yl sulfite
RETADOR

Biological Activity

[Description]:

Propargite is a pesticide used to kill mites. Propargite induces β-cell necrosis preceded by DNA damage. Propargite induces MIN6 cell death with an IC50 of 1 μM[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Ting Zhou, et al. A hPSC-based Platform to Discover Gene-Environment Interactions That Impact Human β-cell and Dopamine Neuron Survival. Nat Commun. 2018 Nov 16;9(1):4815.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
450.7±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₆O₄S

[ Molecular Weight ]:
350.472

[ Flash Point ]:
226.4±28.7 °C

[ Exact Mass ]:
350.155182

[ PSA ]:
63.97000

[ LogP ]:
4.81

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.561

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WT2900000

CHEMICAL NAME :: Sulfurous acid, 2-(p-tert-butylphenoxy)cyclohexyl-2-propynyl ester

CAS REGISTRY NUMBER :: 2312-35-8

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C19-H26-O4-S

MOLECULAR WEIGHT :: 350.51

WISWESSER LINE NOTATION :: L6TJ AOSO&O2UU1 BOR DX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 14,515,1969

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >940 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,719,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued. Volume(issue)/page/year: 9,119,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 780 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 16(1),45,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 10300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A589,1985 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

Safety Information

[ Symbol ]:

GHS05, GHS06, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H318-H331-H351-H410

[ Precautionary Statements ]:
P261-P273-P280-P305 + P351 + P338-P311-P501

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R23;R38;R40;R41;R50/53

[ Safety Phrases ]:
S26-S36/37/39-S45-S60-S61

[ RIDADR ]:
UN 2810

[ RTECS ]:
WT2900000

[ Packaging Group ]:
III

[ Hazard Class ]:
9

[ HS Code ]:
2920909014

Customs

[ HS Code ]: 2920909014

[ Summary ]:
2920909014 2-(4-(tert-butyl)phenoxy)cyclohexyl prop-2-yn-1-yl sulfite。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

Articles

Permeation of Comite through protective gloves.

J. Hazard. Mater. 137(1) , 165-71, (2006)

The goal of the study was to assess how protective disposable (Safeskin) and chemical protective (Sol-Vex) nitrile gloves were against Comite emulsifiable concentrate formulation containing propargite...

Genotoxic effects of the pesticides Rubigan, Omite and Rovral in root-meristem cells of Crepis capillaris L.

Mutat. Res. 652(2) , 191-7, (2008)

Three pesticides have been studied for their genotoxicity by the use of assays in the plant Crepis capillaris, aimed at measuring chromosomal aberrations, micronuclei and sister chromosome exchange (S...

Toxicity of three acaricides to Tetranychus urticae (Tetranychidae: Acari) and Orius insidiosus (Anthocoridae: Hemiptera).

J. Econ. Entomol. 99(1) , 54-9, (2006)

Management for twospotted spider mite, Tetranychus urticae Koch, populations in peanut, Arachis hypogaea L., relies on acaricides. The outcomes of acaricide applications are most predictable when comp...