Thalidomide 4'-ether-alkylC2-amine hydrochloride

Names

[ Name ]:
Thalidomide 4'-ether-alkylC2-amine hydrochloride

Biological Activity

[Description]:

Pomalidomide-PEG1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

Cereblon

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Turk BE, et al. Binding of thalidomide to alpha1-acid glycoprotein may be involved in its inhibition of tumor necrosis factor alpha production. Proc Natl Acad Sci U S A. 1996;93(15):7552‐7556.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₆ClN₃O₅

[ Molecular Weight ]:
353.76

Safety Information

[ Hazard Codes ]:
Xi