Pomalidomide-PEG6-NH2 hydrochloride

Names

[ CAS No. ]:
2341841-01-6

[ Name ]:
Pomalidomide-PEG6-NH2 hydrochloride

Biological Activity

[Description]:

Pomalidomide-PEG6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 6-unit PEG linker used in PROTAC technology.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

Cereblon


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H36ClN3O10

[ Molecular Weight ]:
574.02

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds