IDO1/TDO-IN-3

Names

[ CAS No. ]:
2347579-03-5

[ Name ]:
IDO1/TDO-IN-3

Biological Activity

[Description]:

IDO1/TDO-IN-3 is a potent inhibitor of IDO1/TDO. IDO1/TDO-IN-3 exhibits significant activities against IDO1 (IC50: 0.005 μM) and TDO (IC50: 0.004 μM). IDO1/TDO-IN-3 shows considerable in vivo anti-tumor activity and no obvious toxicity is observed[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)

[References]

[1]. Pan S, et al. Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO). Eur J Med Chem. 2020 Dec 1;207:112703.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H6ClF2N3O2

[ Molecular Weight ]:
345.69

Related Compounds