1,4-Naphthalenedione,2-phenyl-

Names

[ Name ]:
1,4-Naphthalenedione,2-phenyl-

[Synonym ]:
1.4-Dioxo-2-phenyl-naphthalin-dihydrid-(1.4)
1,4-Naphthalenedione,2-phenyl
2-phenyl-1,4-naphthalenedione
2-phenyl-[1,4]naphthoquinone
2-Phenyl-[1,4]naphthochinon
1,4-Naphthoquinone,2-phenyl

Biological Activity

[Description]:

Anti-infective agent 1 (compound 3a) is a potent and selective antiprotozoal and antimycobacterial agent. Anti-infective agent 1 shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC50 values of 10.95 and 0.06 μM, respectively. Anti-infective agent 1 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 8 μg/mL[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Kalt MM, et al. Palladium-catalysed synthesis of arylnaphthoquinones as antiprotozoal and antimycobacterial agents. Eur J Med Chem. 2020 Dec 1;207:112837.

Chemical & Physical Properties

[ Density]:
1.268g/cm3

[ Boiling Point ]:
414.3ºC at 760mmHg

[ Molecular Formula ]:
C₁₆H₁₀O₂

[ Molecular Weight ]:
234.25

[ Flash Point ]:
155ºC

[ Exact Mass ]:
234.06800

[ PSA ]:
34.14000

[ LogP ]:
3.14920

[ Vapour Pressure ]:
4.51E-07mmHg at 25°C

[ Index of Refraction ]:
1.649

Safety Information

[ HS Code ]:
2914690090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914690090

[ Summary ]:
2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%