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E3 ligase Ligand-Linker Conjugates 49

Names

[ CAS No. ]:
2351103-63-2

[ Name ]:
E3 ligase Ligand-Linker Conjugates 49

Biological Activity

[Description]:

E3 ligase Ligand-Linker Conjugates 49 incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 49 can be used to design PROTAC degrader.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

Cereblon


[References]

[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.

Chemical & Physical Properties

[ Molecular Formula ]:
C31H44N4O11

[ Molecular Weight ]:
648.70

Related Compounds