TCO-PEG6-NHS ester

Names

[ CAS No. ]:
2353409-96-6

[ Name ]:
TCO-PEG6-NHS ester

Biological Activity

[Description]:

TCO-PEG6-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H46N2O12

[ Molecular Weight ]:
602.67

Related Compounds