PROTAC VEGFR-2 degrader-2

Names

[ CAS No. ]:
2353417-85-1

[ Name ]:
PROTAC VEGFR-2 degrader-2

Biological Activity

[Description]:

PROTAC VEGFR-2 degrader-2（PROTAC-4）, a PROTAC VEGFR-2 degrader, exhibits little VEGFR-2 inhibition (IC50> 1 μM) and anti-proliferative activity against EA.hy926 cells (IC50> 100μM)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[References]

[1]. Yuanyuan Shan, et al. Discovery of novel anti-angiogenesis agents. Part 11: Development of PROTACs based on active molecules with potency of promoting vascular normalization. Eur J Med Chem. 2020 Nov 1;205:112654.

Chemical & Physical Properties

[ Molecular Formula ]:
C50H56FN9O6S

[ Molecular Weight ]:
930.10

Related Compounds