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Thalidomide-5-propoxyethanamine

Names

[ CAS No. ]:
2357107-60-7

[ Name ]:
Thalidomide-5-propoxyethanamine

[Synonym ]:
1H-Isoindole-1,3(2H)-dione, 5-[3-(2-aminoethoxy)propyl]-2-(2,6-dioxo-3-piperidinyl)-
5-[3-(2-Aminoethoxy)propyl]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

Biological Activity

[Description]:

Thalidomide-5-propoxyethanamine is the Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Mainolfi, Nello, et al. IRAK DEGRADERS AND USES THEREOF. Patent US20190192668A1.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
615.5±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H21N3O5

[ Molecular Weight ]:
359.38

[ Flash Point ]:
326.1±31.5 °C

[ Exact Mass ]:
359.148132

[ LogP ]:
0.45

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.606

Related Compounds