8-bromo-Cyclic AMP

Names

[ Name ]:
8-bromo-Cyclic AMP

[Synonym ]:
8-bromo-cAMP
Cyclic amp,8-bromo
EINECS 245-760-6
8-BR-CAMP
8-BROMOADENOSINE 3' 5'-CYCLIC
B-cAMP
MFCD00075580
8-bromo-adenosine-3',5'-cyclic monophosphate
8-Br-cyclic AMP
8-Bromo-cyclic 3',5'-amp
8-BROMOADENOSINE-3',5'-CYCLOPHOSPHATE
8-Bromoadenosine 3',5'-monophosphate
8-bromo-cyclic AMP
8-BROMOADENOSINE 3':5'-CYCLIC MONOPHOSPHATE

Chemical & Physical Properties

[ Density]:
2.8 g/cm3

[ Boiling Point ]:
741.9ºC at 760 mmHg

[ Melting Point ]:
254ºC (dec.)(lit.)

[ Molecular Formula ]:
C₁₀H₁₁BrN₅O₆P

[ Molecular Weight ]:
408.10200

[ Flash Point ]:
402.5ºC

[ Exact Mass ]:
406.96300

[ PSA ]:
164.65000

[ LogP ]:
0.52630

[ Appearance of Characters ]:
Powder | Pale Brown

[ Vapour Pressure ]:
4.12E-23mmHg at 25°C

[ Index of Refraction ]:
2.037

[ Storage condition ]:
−20°C

[ Water Solubility ]:
aqueous base: soluble

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29349990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Intramitochondrial adenylyl cyclase controls the turnover of nuclear-encoded subunits and activity of mammalian complex I of the respiratory chain.

Biochim. Biophys. Acta 1853(1) , 183-91, (2015)

In mammalian cells the nuclear-encoded subunits of complex I are imported into mitochondria, where they are assembled with mt-DNA encoded subunits in the complex, or exchanged with pre-existing copies...

Antipruritic mechanisms of topical E6005, a phosphodiesterase 4 inhibitor: inhibition of responses to proteinase-activated receptor 2 stimulation mediated by increase in intracellular cyclic AMP.

J. Dermatol. Sci. 76(3) , 206-13, (2014)

Phosphodiesterase 4 (PDE4), which catalyses the conversion of cyclic adenosine 3',5'-monophosphate (cAMP) to 5'-AMP, plays a critical role in the pathogenesis of inflammatory disorders. Pruritus is th...

T-2 toxin regulates steroid hormone secretion of rat ovarian granulosa cells through cAMP-PKA pathway.

Toxicol. Lett. 232(3) , 573-9, (2015)

T-2 toxin is a secondary metabolite produced by Fusarium genus and is a common contaminant in food and feedstuffs of cereal origin. In porcine granulosa cells(GC), T-2 toxin has been shown to inhibit ...