Thalidomide-O-amido-C5-NH2

Names

[ Name ]:
Thalidomide-O-amido-C5-NH2

[Synonym ]:
Acetamide, N-(5-aminopentyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
N-(5-Aminopentyl)-2-{[2-(2,6-dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide

Biological Activity

[Description]:

Thalidomide-O-amide-C5-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

Cereblon

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
757.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₄N₄O₆

[ Molecular Weight ]:
416.428

[ Flash Point ]:
411.8±32.9 °C

[ Exact Mass ]:
416.169586

[ LogP ]:
-0.48

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.599

Safety Information

[ Hazard Codes ]:
Xi

Thalidomide-O-amido-C5-NH2

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds