PROTAC ER Degrader-4

Names

[ Name ]:
PROTAC ER Degrader-4

Biological Activity

[Description]:

PROTAC ER Degrader-4 is a PROATC estrogen receptor (ER) degrader, binding to ER with an IC50 of 0.8 nM. PROTAC ER Degrader-4 induces ER degradation in MCF-7 cells with an IC50 of 0.3 nM[1].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC

[Target]

VHL

[In Vitro]

PROTAC ER Degrader-4 shows equal to 100% ER degradation at 0.3 μM in the MCF-7 ER degradation cellular assay[1].

[References]

[1]. Bin Yang, et al. Compounds and their use in treating cancer. WO2019123367A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₃H₆₇F₃N₆O₈S

[ Molecular Weight ]:
1005.19

[ Storage condition ]:
2-8°C

PROTAC ER Degrader-4

Names

Biological Activity

Chemical & Physical Properties

Related Compounds